P355 Nebulised colistin for patients with cystic fibrosis – time for change?

Bronchoconstriction following nebulised colistin in cystic fibrosis.

Nebulised colistin is regularly used as antipseudomonal therapy in children with cystic fibrosis. We assessed bronchoconstriction in response to nebulised colistin in 58 children. Nebulised colistin significantly reduced FEV(1), MEF(25%), and SaO(2) for 15 minutes. In 20 children the reduction was greater than 10% from baseline FEV(1), and was still at that level in five at 30 minutes. Subjecti...

Nebulised antibiotics for adults with cystic fibrosis.

Nebulised bronchodilators, antibiotics and rhDNase for children with cystic fibrosis.

Bronchodilators syndrome occurring in association with ipratropium. Nebulised bronchodilators are used extensively in children with cystic fibrosis, but in many Optimal dosage regimens for b agonists have not been investigated, and doses given to chilinstances this use is not yet based on objective evidence of clinical benefit. dren with cystic fibrosis are usually similar to those used in asth...

Pharmacokinetics of inhaled colistin in patients with cystic fibrosis.

OBJECTIVES Inhaled colistin is commonly used in patients with cystic fibrosis (CF), but only limited data are available to define its pharmacokinetic profile. PATIENTS AND METHODS We performed a multicentre study in 30 CF patients to assess sputum, serum and urine concentrations after a single dose of 2 million units of colistin administered by inhalation. In a subgroup of patients we also co...

A randomised clinical trial of nebulised tobramycin or colistin in cystic fibrosis.

Chronic infection with Pseudomonas aeruginosa is associated with progressive deterioration in lung function in cystic fibrosis (CF) patients. The purpose of this trial was to assess the efficacy and safety of tobramycin nebuliser solution (TNS) and nebulised colistin in CF patients chronically infected with P. aeruginosa. One-hundred and fifteen patients, aged > or = 6 yrs, were randomised to r...